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KMID : 0981820080280050332
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Korean Journal of Laboratory Medicine
2008 Volume.28 No. 5 p.332 ~ p.338
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Evaluation of Usefulness of the Panel Test Composed of Malaria Non-specific Tests As a Surrogate Marker
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Kang Yun-Hi
Lim Hwan-Sub
Lee Hyuk-Min
Lee Kkot-Sil
Choi Kyong-Min
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Abstract
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Background : Although malaria-specific antibody or antigen test is useful for the diagnosis of malaria infection, its cost-effectiveness has to be concerned in the area where malaria prevalence is very low. We created a panel test composed of malaria non-specific parameters, namely hematology autoanalyzer-derived results with or without addition of HDL-cholesterol data, and evaluated its usefulness in comparison with malaria-specific antibody test.
Methods : For 395 patients tested for malaria smear, the hematology parameters such as platelet count, NRBC (%) and VCS (volume, conductivity, scattering) parameters of WBC, and HDL-cholesterol data were analyzed. Statistical significance of each parameter and that of panel test with or without addition of HDL-cholesterol were evaluated.
Results : Malaria antibody test showed sensitivity of 97.1% and specificity of 99.1%. Each parameter of platelet count, NRBC (%), D parameter and HDL-cholesterol showed sensitivity of 86.8%, 41.2%, 81.8%, and 70.6%, and specificity of 85.9%, 96.3%, 72.3%, and 81.7%, respectively. Panel test without including HDL-cholesterol showed sensitivity of 91.2% and specificity of 81.6%, and that including HDL-cholesterol showed sensitivity of 91.2% and specificity of 86.2%.
Conclusions : The malaria non-specific panel test composed of hematology autoanalyzer-derived parameters showed relatively good, but slightly lower sensitivity than that of malaria-specific antibody test. It might be used as a screening test for the diagnosis of malaria infection, and addition of HDL cholesterol improved little the usefulness of the panel test. (Korean J Lab Med 2008;28:332-8)
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KEYWORD
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Malaria, Diagnosis, Hematology autoanalyzer, HDL-cholesterol
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